Ananthanarayanan Kumar

Ananthanarayanan Kumar's picture
Postdoctoral Fellow

Structural studies of large protein-nucleic acid complexes and dissecting their functions using in vitro biochemical approaches are my primary research interests. My interests are rooted in my engineering background, leading me to pursue a physical and quantitative understanding of important cellular processes. During my PhD, I used electron cryo-microscopy, nuclear magnetic resonance, cross-linking mass spectrometry, and in vitro biochemistry to unravel the molecular architecture and activity of the eukaryotic mRNA 3'-end processing machinery. I believe that an integrative structural biology approach is most suited to understand macromolecular machines as it allows biological processes to be unambiguously elucidated and mechanistic hypotheses to be investigated at an atomic level. As a postdoc at the Pyle laboratory, I will study higher order structures in long non-coding RNAs (lncRNAs) and their associated protein complexes using cryo-EM, chemical probing and other biophysical methods. In particular, I am interested in lncRNAs involved in maintaining genome stability.