Bo Song

Bo Song's picture
Postdoctoral Associate

Melanoma differentiation-associated gene 5 (MDA5) is an important cystosolic RNA sensor that recognizes viral RNAs and, upon activation, induces the production of type I interferons and other inflammatory cytokines. Mutations of human MDA5 have been associated to various autoimmune diseases, such as type 1 diabetes and Aicardi-Goutieres syndrome.  My research project aims to identify the minimal RNA ligand for potent human MDA5 activation. The long-term goal is to understand how human MDA5 recognizes RNAs differentially.