Drug Design

Exploring New Therapeutic Targets through Chemistry and Biology

All of the macromolecular systems studied in the Pyle lab play a central role in human health and disease, although most of them are completely undeveloped as drug targets.  Because our laboratory combines enzymology with structural biology, we are uniquely equipped to explore and develop new therapeutic strategies involving novel targets.  We are using the approaches of Chemical Biology and Medicinal Chemistry to develop small molecule tools for studying our systems of interest, and to develop new therapeutics that will play an important role in our defense against pathogens and cancer.

Exploring the nucleotide binding site of the human innate immune sensor, RIG-I

Relevant Publications

In Silico Discovery of Group II Intron RNA Splicing Inhibitors
Olga Fedorova, Grace Arhin, Anna Marie Pyle, Aaron T Frank
ACS Chemical Biology 2023 () :
Small molecules that target group II introns are potent antifungal agents
Olga Fedorova, G. Erik Jagdmann, Rebecca L. Adams, Lin Yuan, Michael C. Van Zandt and Anna Marie Pyle
Nat Chem Biol 2018 (14) : 1073-1078
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
Xiaoming Ren, Amy D. Gelinas, Ira von Carlowitz, Nebojsa Janjic and Anna Marie Pyle
Nat Commun. 2017 (8) : 810