• November 10, 2021
    Our paper “A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice” published in Journal of Experimental Medicine was featured in...
  • September 12, 2021
    We published an article entitled “The molecular mechanism of RIG-I activation and signaling” to review the role of RIG-I in innate immunity against viral infection.
  • August 17, 2021
    Our grant 1R01HG011868-01 “High-throughput detection of transcriptomic and epitranscriptomic variation and kinetics using MarathonRT” is funded by National Human Genome...
  • July 27, 2021
    The Pyle Lab would like to welcome Zion Perry!
  • June 25, 2021
    Pyle lab has released the first version of rMSA, an automated program to perform database search and alignment to construct a multiple sequence alignment for an input RNA.
  • February 24, 2021
    Our team maps the shape of SARS-CoV-2 genome with an unprecedented level of detail. For the full story, visit Yale News.