Retinoic acid-inducible gene I (RIG-I)-like receptors are cytoplasmic pattern recognition receptors (PRRs) that are crucial in the cytosolic sensing of RNA virus and initiation of innate immune responses. My research of interest is to explore the functional activities of RIG-I like receptors including MDA5 and RIG-I utilizing various biochemical tools. I am also interested in the development of high-throughput FRET based assays.